Modified oligonucleotides for use in gene modulation

摘要

The present invention provides modified oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds are each prepared having a 5'-phosphate precursor which can be modulated to provide a 5'-phosphate group under selected conditions. In another embodiment of the invention the 5'-phosphate precursor is labile inside a target cell thereby providing an oligomeric compounds having a 5'-phosphate intercellularly.