METHOD FOR RESTORATION AND MAINTENANCE OF VITALITY OF AN ISCHEMICALLY DAMAGED DONOR ORGAN

摘要

FIELD: medicine. ^ SUBSTANCE: invention is referred to the area of medicine, namely to transplantology and can be used for restoration and maintenance of vitality of an ischemically damaged donor organ. Before explantation of organ from donor body for 2-3 hours the normothermic perfusion of abdominal blood supply regions is performed using pulsating flow of oxygen enriched perfusate on the basis of blood, from which the activated leucocytes and underoxidized products of biochemical decay are removed additionally. The explantation of organ out of donor's body is performed. The normothermic perfusion of isolated organ is performed. During the organ perfusion process the estimation of its viability for transplantation is performed. The initial systolic pressure is established as 35 mm Hg in case of optimal implant state, 40-45 mm Hg for implants with borderline ischemic damage. Then the estimation is performed for degree of opening of circulatory bed of an organ by alteration of resistive index value. If within the period of 4-6 hours the resistive index does not increase or decrease the organ is presumed not viable for transplantation. If within this time the value of resistive index decreases by 2-3 fold and the flow speed is established within 80-150 ml/min the perfusion is continued till the moment of donor organ transplantation. ^ EFFECT: restoration of vitality of donor organs with borderline characteristics; clear estimation of its viability for transplantation and long-time maintenance of functional state of a transplantation viable organ. ^ 1 dwg, 2 dwg, 2 ex