发明名称 |
MICE THAT MAKE BINDING PROTEINS COMPRISING VL DOMAINS |
摘要 |
Genetically modified mice and methods for making an using them are provided, wherein the mice comprise a replacement of all or substantially all immunoglobulin heavy chain V gene segments, D gene segments, and J gene segments with at least one light chain V gene segment and at least one light chain J gene segment. Mice that make binding proteins that comprise a light chain variable domain operably linked to a heavy chain constant region are provided. Binding proteins that contain an immunoglobulin light chain variable domain, including a somatically hypermutated light chain variable domain, fused with a heavy chain constant region, are provided. Modified cells, embryos, and mice that encode sequences for making the binding proteins are provided. |
申请公布号 |
CA2807282(A1) |
申请公布日期 |
2012.02.09 |
申请号 |
CA20112807282 |
申请日期 |
2011.08.02 |
申请人 |
REGENERON PHARAMACEUTICALS, INC. |
发明人 |
MACDONALD, LYNN;STEVENS, SEAN;GURER, CAGAN;HOSIAWA, KAROLINA A.;MURPHY, ANDREW J. |
分类号 |
C12N15/85;A01K67/027;C07K16/00 |
主分类号 |
C12N15/85 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|