发明名称 |
MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS |
摘要 |
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. |
申请公布号 |
US2012034246(A1) |
申请公布日期 |
2012.02.09 |
申请号 |
US201113090246 |
申请日期 |
2011.04.19 |
申请人 |
DORONINA SVETLANA O.;SENTER PETER D.;TOKI BRIAN E.;EBENS ALLEN J.;KLINE TONI BETH;POLAKIS PAUL;SLIWKOWSKI MARK X.;SPENCER SUSAN D.;SEATTLE GENETICS, INC. |
发明人 |
DORONINA SVETLANA O.;SENTER PETER D.;TOKI BRIAN E.;EBENS ALLEN J.;KLINE TONI BETH;POLAKIS PAUL;SLIWKOWSKI MARK X.;SPENCER SUSAN D. |
分类号 |
A61K39/395;A61K38/00;A61K38/06;A61K47/48;A61P35/00;C07K16/30;C07K16/46 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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