| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for simply producing (S)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine by high-yielding and excellently operable optical resolution. <P>SOLUTION: An optically active dicarboxylic acid selected from among di-p-toluoyl-D-tartaric acid, di-p-anisoyl-D-tartaric acid and (1R, 2R)-cyclohexanedicarboxylic acid is caused to react with racemic 4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine in a mixed solvent of a 1-4C alcohol with a solvent selected from among amides and esters to give a diastereomer salt of (S)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine, which is crystallized in the mixed solvent and subsequently fractionated to give the diastereomer salt. <P>COPYRIGHT: (C)2012,JPO&INPIT |
