| 发明名称 |
MODIFIED HEPARINASE III AND METHODS OF SEQUENCING THEREWITH |
| 摘要 |
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
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| 申请公布号 |
US2012027744(A1) |
申请公布日期 |
2012.02.02 |
| 申请号 |
US201113076066 |
申请日期 |
2011.03.30 |
| 申请人 |
LIU DONGFANG;POJASEK KEVIN;SHRIVER ZACHARY;HOLLEY KRISTINE;EL-SHABRAWI YOSUF;VENKATARAMAN GANESH;SASISEKHARAN RAM;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
LIU DONGFANG;POJASEK KEVIN;SHRIVER ZACHARY;HOLLEY KRISTINE;EL-SHABRAWI YOSUF;VENKATARAMAN GANESH;SASISEKHARAN RAM |
| 分类号 |
A61K38/51;C12N15/09;A61K31/7016;A61K31/726;A61K38/00;A61K45/00;A61K47/48;A61K48/00;A61P9/00;A61P17/06;A61P27/02;A61P35/00;A61P35/04;C08B37/00;C08B37/10;C12N5/09;C12N9/24;C12N9/88;C12N15/60;C12P19/26;C12P19/28;C12Q1/34;C12Q1/527 |
主分类号 |
A61K38/51 |
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