发明名称 |
CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING AND PHOTOACOUSTIC IMAGING METHOD USING THE SAME |
摘要 |
It is intended to provide a novel contrast agent for photoacoustic imaging that is highly capable of binding to a target molecule and generates high photoacoustic signals. The present invention provides a contrast agent for photoacoustic imaging represented by Formula 1: MNP−((L)l−(P)m)n (Formula 1) (wherein MNP represents a particle containing an iron oxide particle; L represents a linker molecule; P represents a ligand molecule; l represents 0 or 1; and m and n represent an integer of 1 or larger), the contrast agent for photoacoustic imaging including: a particle containing an iron oxide particle that absorbs light in a near-infrared region; and at least one or more ligand molecule(s) immobilized on the particle containing an iron oxide particle, wherein the immobilization density of the ligand molecule is equal to or higher than the cell surface density of a target molecule.
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申请公布号 |
US2012027679(A1) |
申请公布日期 |
2012.02.02 |
申请号 |
US201113112135 |
申请日期 |
2011.05.20 |
申请人 |
CANON KABUSHIKI KAISHA |
发明人 |
YAMAUCHI FUMIO;OGAWA SATOSHI;KANAZAKI KENGO;INOUE SACHIKO;FUKUI TATSUKI;MINAMI MASATO;KISHI MAYUKO |
分类号 |
A61K49/00;B32B5/16;B82Y15/00;C07K17/14;G01N33/574 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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