发明名称 |
METHOD FOR MANUFACTURING A BORONIC ACID ESTER COMPOUND |
摘要 |
<p>The present invention relates to a method for manufacturing a boronic acid ester compound, characterized by reacting an aryl halide compound and a diboron ester compound in the presence of a nitrogen-containing organic base, a nickel catalyst, a phosphine compound and a solvent. According to the manufacturing method of the present invention, even if a nickel catalyst is used as the catalyst, a desired boronic acid ester compound can be obtained in a sufficiently high yield. Furthermore, even if aryl chloride or aryl bromide having relatively low price and low reactivity, was used as the aryl halide compound, a desired boronic acid ester compound can be obtained in a sufficiently high yield.</p> |
申请公布号 |
EP2411398(A1) |
申请公布日期 |
2012.02.01 |
申请号 |
EP20090842417 |
申请日期 |
2009.03.24 |
申请人 |
SUMITOMO CHEMICAL COMPANY, LIMITED;GENENTECH, INC. |
发明人 |
MIKI, TAKASHI;SHIMASAKI, YASUHARU;BABU, SRINIVASAN;CHENG, ZHIGANG;REYNOLDS, MARK, E.;TIAN, QINGPING |
分类号 |
C07F5/04 |
主分类号 |
C07F5/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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