发明名称 |
Solid Pharmaceutical Dosage Form |
摘要 |
A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.
|
申请公布号 |
US2012022089(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
US201113240119 |
申请日期 |
2011.09.22 |
申请人 |
ROSENBERG JOEERG;REINHOLD ULRICH;LIEPOLD BERND;BERNDL GUNTHER;BREITENBACH JOERG;ALANI LAMAN L.;GHOSH SOUMOJEET;ABBOTT LABORATORIES |
发明人 |
ROSENBERG JOEERG;REINHOLD ULRICH;LIEPOLD BERND;BERNDL GUNTHER;BREITENBACH JOERG;ALANI LAMAN L.;GHOSH SOUMOJEET |
分类号 |
A61K31/513;A61K9/16;A61K9/20;A61K31/427 |
主分类号 |
A61K31/513 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|