发明名称 |
PEPTIDES BASED ON THE TRANSMEMBRANE DOMAIN OF A TOLL-LIKE RECEPTOR (TLR) FOR TREATMENT OF TLR-MEDIATED DISEASES |
摘要 |
Peptides are provided that are capable of inhibiting cell activation mediated by a Toll-like receptor (TLR) selected from TLR 1, 2, 4 or 6, said peptide comprising a sequence consisting of, or found within, the sequence of the transmembrane domain of a TLR selected from TLR 1, 2, 4 or 6 and optionally cytoplasmic and extracellular regions flanking the transmembrane domain. These peptides as well as pharmaceutical composition comprising them are useful for the treatment of TLR-mediated disease. |
申请公布号 |
CA2805989(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
CA20112805989 |
申请日期 |
2011.07.19 |
申请人 |
YEDA RESEARCH AND DEVELOPMENT CO. LTD. |
发明人 |
SHAI, YECHIEL;FINK, AVNER;REUVEN, ELIRAN-MOSHE;SHMUEL-GALIA, LIRAZ |
分类号 |
C07K7/08 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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