发明名称 |
SUBSTITUTED 3-PHENYL-1,2,4-OXADIAZOLE COMPOUNDS |
摘要 |
<p>Disclosed are compounds of Formula (I): (I) or stereoisomers, salts, or prodrugs thereof, wherein: (i) R1 and R2 are independently C1-C4 alkyl, or (ii) R1 and R2 together with the carbon atom to which they are attached, form a cyclic group; and Q is H, C1-6alkyl, phenyl or 5- to 6-membered heteroaryl substituted with zero to 3 substituents, and G is defined herein. Also disclosed are method of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. There compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and chronic inflammatory disease.</p> |
申请公布号 |
WO2012012477(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
WO2011US44597 |
申请日期 |
2011.07.20 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;DAS, JAGABANDHU;KO, SOO SUNG;SRIVASTAVA, ANURAG;MOQUIN, ROBERT V.;WATTERSON, SCOTT H. |
发明人 |
DAS, JAGABANDHU;KO, SOO SUNG;SRIVASTAVA, ANURAG;MOQUIN, ROBERT V.;WATTERSON, SCOTT H. |
分类号 |
C07D271/06;A61K31/4245;A61P9/00;A61P37/00;C07D413/10;C07D413/14 |
主分类号 |
C07D271/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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