Pre-coated surfaces for analysis

摘要

Sample preparation can be a tedious and time consuming task. For example, MALDI imaging of tissue samples can require the tedious process of hand or robotically spotting solutions containing chemical species referred to as“matrix”onto a tissue sample prior its mass spectral analysis. Provided is a process for preparing a sample comprising immersing a solid support that has a surface comprising a first part that is more hydrophilic than a second part into a target compound solution, wherein the target compound is deposited primarily onto the more hydrophilic part; and/or applying and evaporating the target compound solution onto the substrate to produce the pre-coated substrate. A tissue or other sample may then be placed on the substrate for analysis.