发明名称 |
Attenuated FNR deficient enterobacteria |
摘要 |
The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated enterobacteria of the invention. Further disclosed are methods of inducing an immune response in a subject by administration of an immunogenically effective amount of an attenuated enterobacterium or pharmaceutical formulation of the invention. |
申请公布号 |
US8101168(B2) |
申请公布日期 |
2012.01.24 |
申请号 |
US20090500366 |
申请日期 |
2009.07.09 |
申请人 |
HASSAN HOSNI M.;FINK RYAN C.;EVANS MATTHEW R.;NORTH CAROLINA STATE UNIVERSITY |
发明人 |
HASSAN HOSNI M.;FINK RYAN C.;EVANS MATTHEW R. |
分类号 |
A01N63/00;A61K39/112;C12N1/36 |
主分类号 |
A01N63/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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