发明名称 |
Hydroxybenzamide derivatives and their use as inhibitors of HSP90 |
摘要 |
The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydrogen; R2 is hydroxy or methoxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors. |
申请公布号 |
US8101648(B2) |
申请公布日期 |
2012.01.24 |
申请号 |
US20060911490 |
申请日期 |
2006.04.13 |
申请人 |
CHESSARI GIANNI;CONGREVE MILES STUART;NAVARRO EVA FIGUEROA;FREDERICKSON MARTYN;MURRAY CHRISTOPHER;WOOLFORD ALISON JO-ANNE;CARR MARIA GRAZIA;O'BRIEN MICHAEL ALISTAIR;WOODHEAD ANDREW JAMES;DOWNHAM ROBERT;PHILLIPS THERESA RACHEL;ASTEX THERAPEUTICS, LTD. |
发明人 |
CHESSARI GIANNI;CONGREVE MILES STUART;NAVARRO EVA FIGUEROA;FREDERICKSON MARTYN;MURRAY CHRISTOPHER;WOOLFORD ALISON JO-ANNE;CARR MARIA GRAZIA;O'BRIEN MICHAEL ALISTAIR;WOODHEAD ANDREW JAMES;DOWNHAM ROBERT;PHILLIPS THERESA RACHEL |
分类号 |
A01N43/38;A61K31/40;C07D209/44 |
主分类号 |
A01N43/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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