SYNTHESIS OF PHOSPHITYLATED COMPOUNDS USING QUATERNARY HETEROCYCLIC ACTIVATOR

摘要

FIELD: chemistry. ^ SUBSTANCE: method involves reaction of a hydroxyl-containing compound, which contains a sugar fragment, with a phosphitylation agent in the presence of an activator of formula I , where R = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl, R1, R2 = either H, or together form a 5-6-member ring, X1, X2 = independently N or CH, Y = H or Si(R4)3, where R4 = alkyl, cycloalkyl, aryl, aralkyl, heteroalkyl, heteroaryl, B = trifluoroacetate, dichloroacetate, mesyl, tosyl, o-chlorophenolate. ^ EFFECT: novel method of producing phosphoramidites. ^ 17 cl, 21 ex