A NOVEL SUSTAINED RELEASE COMPOSITION OF COMPOUNDS SELECTED FROM THE CLASS OF CENTRALLY ACTING MUSCLE RELAXANTS

摘要

The disclosed invention provides novel sustained release pharmaceutical preparations and process for making such compositions of Tolperisone and/or Eperisone and/or a pharmaceutically acceptable salt thereof. The present invention provides a sustained release formulation of Tolperisone and Eperisone either single or in combination or otherwise in combination with other drugs selected from the classes such as analgesic, antipyretic, neuroprotective agents, other muscle relaxants which can be formulated either in a fixed dose or as combination kit for oral administration. The composition is suitable for once a day administration into mammals and provides sustained and prolonged drug release till 24 hours which helps to reduce dosing frequency. The composition comprises therapeutically effective amount of active substance, release retarding polymers and other pharmaceutically acceptable excipients.