发明名称 |
2-INDOLYL IMIDAZO[4,5-D]PHENANTHROLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER |
摘要 |
2-indolyl imidazo[4,5-dlphenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Formula I can also induce apoptosis in cancer cells and are thus capable of exerting a cytotoxic effect on cancer cells. The compounds of Formula I are also capable of selectively inhibiting the proliferation of one or more of prostate cancer cells, colon cancer cells, non-small lung cancer cells and leukemia cells. The compounds of Formula I are also capable of increasing the expression of the zinc-regulated tumour suppressor, KLF4 and thus are useful in inhibiting the proliferation of cancer cells in which KLF4 functions as a tumour-suppressor, including, but not limited to, bladder cancer, cancers of the gastrointestinal tract and various leukemias.
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申请公布号 |
CA2611032(C) |
申请公布日期 |
2012.01.17 |
申请号 |
CA20062611032 |
申请日期 |
2006.05.25 |
申请人 |
GENESENSE TECHNOLOGIES INC. |
发明人 |
HUESCA, MARIO;KHINE, AYE-AYE;LEE, YOON;LOCK, LISA;WRIGHT, JIM A.;YOUNG, AIPING H.;AL-QAWASMEH, RAED |
分类号 |
C07D471/14;A61K31/4745;A61P35/00 |
主分类号 |
C07D471/14 |
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