发明名称 |
VACCINES AGAINST WEST NILE VIRUS |
摘要 |
The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived there from, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (El) gene product of an adenovirus. The cells are preferably cultured in suspension to very high densities and under serum-free conditions. Herein, it is disclosed that use of such cells results in high titers of West Nile Virus produced. |
申请公布号 |
CA2501220(C) |
申请公布日期 |
2012.01.17 |
申请号 |
CA20032501220 |
申请日期 |
2003.11.07 |
申请人 |
CRUCELL HOLLAND B.V. |
发明人 |
UYTDEHAAG, ALPHONSUS GERARDUS CORNELIS MARIA;SCHOUTEN, GOVERT JOHAN;GOUDSMIT, JAAP |
分类号 |
C12N5/10;A61K39/12;C07K14/18;C12N7/00;C12N7/04 |
主分类号 |
C12N5/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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