| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a respiratory syncytial virus (RSV) therapy and a composition and a method for modulating viral replication. <P>SOLUTION: The invention is based on the in vivo demonstration that RSV can be inhibited through intranasal administration of iRNA agents as well as by parenteral administration of such agents. Further, it is shown that effective viral reduction can be achieved with more than one virus being treated concurrently. Based on these findings, there is provided the general and specific composition and method that are useful in reducing RSV mRNA levels, RSV protein levels and viral titers in a subject, e.g., a mammal, such as a human. These findings can be applied to other respiratory viruses. <P>COPYRIGHT: (C)2012,JPO&INPIT |
