| 发明名称 |
FUSED HETEROCYCLIC DERIVATIVES AS S1P MODULATORS |
| 摘要 |
<p>The present invention relates to a fused heterocyclic derivative of the formula (I) The variables R1-R4, z, A, Q, X and Y are as defined in the claims. The following heterocycles are exemplified substructures of formula (I): The compounds of formula (I) are modulators of the S1P receptor (Sphingosine-1-phosphate receptor), More specifically, they are agonists of S1P5. The compounds have therapeutic use in treatment of cognitive disorders, age-relate cognitive decline and dementia.</p> |
| 申请公布号 |
CA2804137(A1) |
申请公布日期 |
2012.01.12 |
| 申请号 |
CA20112804137 |
申请日期 |
2011.07.08 |
| 申请人 |
ABBVIE B.V. |
发明人 |
SMID, PIETER;IWEMA BAKKER, WOUTER I.;COOLEN, HEIN K.A.C.;SLIEDREGT, LEONARDUS A.J.M.;VAN DONGEN, MARIA J.P.;DEN HARTOG, JACOBUS A.J. |
| 分类号 |
C07D487/04;A61K31/429;A61K31/4355;A61K31/4365;A61K31/437;A61K31/55;A61P25/28;C07D491/04;C07D498/04;C07D513/04 |
主分类号 |
C07D487/04 |
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