发明名称 Indazoles as glucocorticoid receptor ligands
摘要 A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.
申请公布号 US8093281(B2) 申请公布日期 2012.01.10
申请号 US20060910935 申请日期 2006.04.12
申请人 ELDRED COLIN DAVID;HOUSE DAVID;INGLIS GRAHAM GEORGE ADAM;MACDONALD SIMON JOHN FAWCETT;SKONE PHILIP ALAN;GLAXO GROUP LIMITED 发明人 ELDRED COLIN DAVID;HOUSE DAVID;INGLIS GRAHAM GEORGE ADAM;MACDONALD SIMON JOHN FAWCETT;SKONE PHILIP ALAN
分类号 A61K31/416;C07D231/56 主分类号 A61K31/416
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