发明名称 |
NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES |
摘要 |
Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity. |
申请公布号 |
WO2011132083(A3) |
申请公布日期 |
2012.01.05 |
申请号 |
WO2011IB01289 |
申请日期 |
2011.04.19 |
申请人 |
ACTAVIS GROUP PTC EHF;KHILE, ANIL, SHAHAJI;PATEL, JAYESH;TRIVEDI, NIKHIL;PRADHAN, NITIN, SHARADCHANDRA |
发明人 |
KHILE, ANIL, SHAHAJI;PATEL, JAYESH;TRIVEDI, NIKHIL;PRADHAN, NITIN, SHARADCHANDRA |
分类号 |
C07C45/46;C07C49/233;C07C201/10;C07C201/12;C07C205/10;C07C205/16;C07C205/45;C07C209/34 |
主分类号 |
C07C45/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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