发明名称 |
Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases |
摘要 |
The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size. The present invention also relates to methodology for polymer grafting by a polysaccharide synthase to form glycosaminoglycan polymers having an unnatural structure. |
申请公布号 |
US8088604(B2) |
申请公布日期 |
2012.01.03 |
申请号 |
US20070906704 |
申请日期 |
2007.10.03 |
申请人 |
DEANGELIS PAUL L.;SISMEY-RAGATZ ALISON;THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA |
发明人 |
DEANGELIS PAUL L.;SISMEY-RAGATZ ALISON |
分类号 |
C12P19/18;C12P19/00;C12P19/04 |
主分类号 |
C12P19/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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