NUOVI COMPLESSI DI INCLUSIONE FARMACEUTICI, SOLIDI, SOLUBILI IN ACQUA E LE LORO SOLUZIONI ACQUOSE PER USO ORALE, OFTALMICO, TOPICO O PARENTERALE, CONTENENTI UN MACROLIDE ED ALCUNE CICLODESTRINE.NEW WATER-SOLUBLE SOLID PHARMACEUTICAL INCLUSION COMPLEX

摘要

This invention relates to new water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins. More particularly the invention relates to new water-soluble solid pharmaceutical inclusion complexes and their solutions in aqueous solvents, said compositions containing
a) as an active ingredient a macrolide such as Rapamycin, Pimecrolimus, Temsirolimus, Everolimus or Tacrolimus in an amorphous form and optionally in the form of their polymorphic hydrates or solvates e.g. solvates formed with acetone or ethanol.
b) a large surface cyclodextrin, such as gamma cyclodextrin -whereby the weight ratio of said macrolide to said cyclodextrin ranges between 1:111 and 1:333.