发明名称 |
METHODS FOR TREATMENT OF AUTOIMMUNE DISEASES USING NEUTROKINE-ALPHA ANTAGONIST |
摘要 |
The present invention relates to methods and compositions for use in treatment of patients with autoantibody positive disease. In a specific embodiment, the present invention relates to a method of treating a patient that has an ANA titer of 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodies in his/her blood plasma or serum comprising administering a therapeutically effective amount of an immunomodulatory agent, such as an antagonist of Neutrokine-alpha. Additionally provided is a method of reducing the frequency and/or quantity of corticosteroid administration to patients. In preferred embodiments, the patient has systemic lupus erythematosus. Methods for determining if a lupus patient is responding to medical treatment are also provided. |
申请公布号 |
EA015860(B1) |
申请公布日期 |
2011.12.30 |
申请号 |
EA20080001071 |
申请日期 |
2006.10.05 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
CHEVRIER MARC;FRIEMUTH WILLIAM;ZHONG ZHENSHAO;ODENHEIMER DANIEL;PERKINS MELISSA, D. |
分类号 |
C12P21/06;A61K39/395;A61K49/00;A61P37/00;C07H21/04;C07K16/00 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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