C1ORF59 FOR TARGET GENES OF CANCER THERAPY AND DIAGNOSIS

摘要

Objective methods for diagnosing a predisposition to developing cancer are described herein. In one embodiment, the diagnostic method involves determining an expression level of the C1orf59 gene, the PIWIL4 gene, or piRNA and correlating the determined level with a healthy, diseased or at-risk state. The present invention further provides methods of assessing or determining the prognosis of a patient with esophageal cancer. In one embodiment, the diagnostic method involves determining an expression level of the C1orf59 gene. The present invention further provides methods of screening for therapeutic substances useful in the treatment of a C1orf59-, and/or PIWIL4-associated disease, such as a cancer. The present invention further provides methods of treating or preventing a cancer expressing the C1orf59 gene and/or the PIWIL4 gene. The present invention also features products, including double-stranded molecules and vectors encoding thereof as well as to compositions including them.