发明名称 |
TOLVAPTAN SOLID DISPERSION AND ITS PREPARATION METHOD |
摘要 |
A tolvaptan solid dispersion and its preparation method are disclosed. The solid dispersion comprises tolvaptan and crosslinked polyvinylpyrrolidone, at a weight ratio of 1:0.05-20, preferably 1:0.1-10, more preferably 2:1.The solid dispersion can also comprise water-soluble polymers, such as polyvinylpyrrolidone, hydroxypropylcellulose, hydroxyethylcellulose or methylcellulose. The weight ratio of tolvaptan : crosslinked polyvinylpyrrolidone : water-soluble polymers preferably is 2:1:0.1. The solid dispersion exhibits good thermodynamic stability and solubility. The pharmaceutical composition thereof has improved release rate and bioavailability. |
申请公布号 |
WO2011160541(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
WO2011CN75131 |
申请日期 |
2011.06.02 |
申请人 |
JIANGSU HENGRUI MEDICINE CO., LTD.;WU, YUXIA;MAO, SHUJUN;CHEN, HAO |
发明人 |
WU, YUXIA;MAO, SHUJUN;CHEN, HAO |
分类号 |
A61K47/32;A61K9/14;A61K31/55;A61K47/36;A61K47/38;A61P7/10 |
主分类号 |
A61K47/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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