发明名称 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER |
摘要 |
Methods for inducing an immune response to a tumor in a subject are disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the CpG ODN is a K-type or a D-type CpG ODN. Methods for treating a tumor in a subject are also disclosed herein. These methods include selecting a subject with a tumor and administering a therapeutically effective amount of apopototic tumor cells conjugated to a CpG oligodexoynucleotide (ODN) to the subject. In some embodiments, the tumor cells are autologous. In additional embodiments, the tumor is a lymphoma, cervical cancer, prostate cancer, breast cancer, colon cancer or a lung cancer. |
申请公布号 |
WO2011109422(A3) |
申请公布日期 |
2011.12.29 |
申请号 |
WO2011US26727 |
申请日期 |
2011.03.01 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;KLINMAN, DENNIS;SHIROTA, HIDEKAZU |
发明人 |
KLINMAN, DENNIS;SHIROTA, HIDEKAZU |
分类号 |
A61K47/48;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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