发明名称 |
METHODS OF PRODUCING HUMANIZED NON-HUMAN MAMMALS |
摘要 |
<p>Provided herein are methods of reconstituting functional human blood cell lineages in a non-human mammal comprising introducing human hematopoietic stem cells (HSCs) and nucleic acid encoding one or more human cytokines into an immunodeficient non-human mammal. The non-human mammal is maintained under conditions in which the nucleic acid is expressed and the human HSCs differentiate into functional human blood cell lineages in the non-human mammal, thereby reconstituting functional human blood cell lineages in the non-human mammal. Also provided are methods of producing human antibodies directed against an immunogen in a non-human mammal, hybridomas that secrete the monoclonal antibodies as well as antibodies (e.g., polyclonal antibodies; monoclonal antibodies) produced by the B cells and non-human mammals produced by the methods.</p> |
申请公布号 |
SG176118(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
SG20110084647 |
申请日期 |
2010.06.28 |
申请人 |
CHEN, QINGFENG;CHEN, JIANZHU |
发明人 |
CHEN, QINGFENG;CHEN, JIANZHU |
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