发明名称 |
METHOD FOR ENHANCING A FUNCTION OF A T CELL |
摘要 |
Disclosed is a method for enhancing the function of a T cell, which is characterized by inhibiting the expression of programmed death-1 ligand 1 (PD-L1) and/or programmed death-1 ligand 2 (PD-L2) in the T cell. Also disclosed is a function-enhanced T cell which is produced by the function enhancement method. Further disclosed is a therapeutic agent comprising the function-enhanced T cell. The T cell can enhance an immune response to cancer, and is useful in an immunotherapy effective for cancer and the treatment or prevention of infectious diseases and autoimmune diseases. |
申请公布号 |
US2011318839(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US201013254602 |
申请日期 |
2010.03.05 |
申请人 |
SHIKU HIROSHI;IKEDA HIROAKI;IWAMURA KOICHI;MINENO JUNICHI;KATO IKUNOSHIN |
发明人 |
SHIKU HIROSHI;IKEDA HIROAKI;IWAMURA KOICHI;MINENO JUNICHI;KATO IKUNOSHIN |
分类号 |
C12N5/0783 |
主分类号 |
C12N5/0783 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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