发明名称 |
NON-HUMAN ANIMAL MODEL FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) WITH LOSS-OF-TDP-43 FUNCTION |
摘要 |
A non-human animal model for amyotrophic lateral sclerosis (ALS) is disclosed. The animal model comprises a rodent whose spinal cord motor neurons have a loss of TAR-DNA binding protein-43 (TDP-43) function and phenotypes exhibit ALS-like symptoms. A method for identifying a candidate agent for treating, preventing and/or inhibiting ALS associated with a loss-of-function of TDP-43 is also disclosed. |
申请公布号 |
US2011321179(A1) |
申请公布日期 |
2011.12.29 |
申请号 |
US201113166147 |
申请日期 |
2011.06.22 |
申请人 |
SHEN CHE-KUN JAMES;WU LIEN-SZU;ACADEMIA SINICA |
发明人 |
SHEN CHE-KUN JAMES;WU LIEN-SZU |
分类号 |
A01K67/033;A61K49/00;C12N5/07;C12N5/10 |
主分类号 |
A01K67/033 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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