METHOD FOR PREPARING [1,2,3]-OXATHIAZOLIDINE-2,2-DIOXIDE OR [1,2,5]-THIADIAZOLIDINE-1,1-DIOXIDE DERIVATIVES

摘要

PURPOSE: A method for preparing [1,2,3]-oxathiazolidine-2,2-dioxide or derivative thereof is provided to simply and efficiently obtain the enantiomerically pure compounds. CONSTITUTION: A method for preparing a compound of chemical formula 1a or 1b with optical activity comprises a step of performing asymmetric reduction of a compound of chemical formula 2 under the presence of a hydrogen donor and a rhodium compound catalyst containing pentamethylcyclopentadienyl group. The hydrogen donor is formic acid, metal salt thereof of. The compound of chemical formula 2 is prepared by reacting alpha-hydroxy ketone of chemical formula 4 with sulfamide of chemical formula 5 by thermal reflux or under an acidic condition.