发明名称 |
Methods and compositions for diagnosing gastrointestinal stromal tumors |
摘要 |
<p>The present invention relates to an in vitro method for diagnosing and/or monitoring in a subject a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising detecting and/or analyzing in a test sample derived from the subject one or more mutations in any one or both of the marker genes cKIT (GenBank acc. no. NM_000222.2) and PDGFRA (GenBank acc. no. NM_006206.4), wherein the presence of any one of the mutations detected in the test sample is indicative of a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor in the subject. The present invention is also directed to a corresponding kit-of-parts for diagnosing and/or monitoring a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor, comprising means for detecting and/or analyzing one or more mutations as defined herein, as well as to the use of one or more mutations as defined herein as a panel of molecular markers for diagnosing and/or monitoring a gastrointestinal stromal tumor or a predisposition to develop a gastrointestinal stromal tumor.</p> |
申请公布号 |
EP2400035(A1) |
申请公布日期 |
2011.12.28 |
申请号 |
EP20100167588 |
申请日期 |
2010.06.28 |
申请人 |
TECHNISCHE UNIVERSITAET MUENCHEN;UNIVERSITAET LEIPZIG |
发明人 |
VON BUBNOFF, NIKOLAS;LANGE, THORALF;MAIER, JACQUELINE |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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