摘要 |
The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention. |
申请人 |
MERCK SHARP & DOHME CORP.;ISIS PHARMACEUTICALS, INC. |
发明人 |
CARROLL, STEVEN S;LAFEMINA, ROBERT L;HALL, DAWN L;HIMMELBERGER, AMY L;KUO, LAWRENCE C;MACCOSS, MALCOLM;OLSEN, DAVID B;RUTKOWSKI, CARRIE A;TOMASSINI, JOANNE E;AN, HAOYUN;BHAT, BALKRISHEN;BHAT, NEELIMA;COOK, PHILLIP DAN;ELDRUP, ANNE B;GUINOSSO, CHARLES J;PRHAVC, MARIJA;PRAKASH, THAZHA P. |