摘要 |
The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives. |
申请人 |
CHOIDAS AXEL;BACKES ALEXANDER;COTTEN MATT;ENGKVIST OLA;FELBER BEATRICE;FREISLEBEN ACHIM;GODL KLAUS;GREFF ZOLTAN;HABENBERGER PETER;HAFENBRADL DORIS;HARTUNG CHRISTIAN;HERGET THOMAS;HOPPE EDMUND;KLEBL BERT;MISSIO ANDREA;MUELLER GERHARD;SCHWAB WILFRIED;ZECH BIRGIT;BRAVO JOSE;HARRIS JOHN;LE JOELLE;MACRITCHIE JACKIE;SAVIC VLADIMIR;SHERBORNE BRAD;SIMPSON DON;LEAD DISCOVERY CENTER GMBH;BAYER PHARMA AG |
发明人 |
CHOIDAS AXEL;BACKES ALEXANDER;COTTEN MATT;ENGKVIST OLA;FELBER BEATRICE;FREISLEBEN ACHIM;GODL KLAUS;GREFF ZOLTAN;HABENBERGER PETER;HAFENBRADL DORIS;HARTUNG CHRISTIAN;HERGET THOMAS;HOPPE EDMUND;KLEBL BERT;MISSIO ANDREA;MUELLER GERHARD;SCHWAB WILFRIED;ZECH BIRGIT;BRAVO JOSE;HARRIS JOHN;LE JOELLE;MACRITCHIE JACKIE;SAVIC VLADIMIR;SHERBORNE BRAD;SIMPSON DON |