Compounds comprising 4-benzoylpiperidine as a Sigma-1-selective ligand

摘要

Bipiperidinyl compounds and salts thereof are disclosed. The compounds include high affinity ligands for &sgr;1 receptors. Some compounds are also highly selective for &sgr;1 receptor compared to &sgr;2 receptor. Compounds can comprise radioisotopes, including 18F or 11C. Radiolabeled compounds can be used as probes for imaging distribution of &sgr;1 receptor in a subject such as a human using positron emission tomography (PET) scanning.