BI-SPECIFIC ANTIBODIES AGAINST TIM-3 AND PD-1 FOR IMMUNOTHERAPY IN CHRONIC IMMUNE CONDITIONS
摘要
Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors PD-1 and TIM-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as persistent infections or cancer.
申请公布号
WO2011159877(A2)
申请公布日期
2011.12.22
申请号
WO2011US40665
申请日期
2011.06.16
申请人
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;KUCHROO, VIJAY K.;ANDERSON, ANA, C.