发明名称 |
Albumin variants and conjugates |
摘要 |
Based on the three-dimensional structure of albumin, the inventors have designed variant polypeptides (muteins) which have one or more cysteine residues with a free thiol group (hereinafter referred to as “thio-albumin”). The variant polypeptide may be conjugated through the sulphur atom of the cysteine residue to a conjugation partner such as a bioactive compound. |
申请公布号 |
US2011313133(A1) |
申请公布日期 |
2011.12.22 |
申请号 |
US201013201123 |
申请日期 |
2010.02.11 |
申请人 |
FINNIS CHRISTOPHER JOHN ARTHUR;HAY JOANNA MARY;FRIIS ESBEN PETER;CAMERON JASON;SLEEP DARRELL;NOVOZYMES A/S;NOVOZYMES BIOPHARMA DK A/S |
发明人 |
FINNIS CHRISTOPHER JOHN ARTHUR;HAY JOANNA MARY;FRIIS ESBEN PETER;CAMERON JASON;SLEEP DARRELL |
分类号 |
C07K14/76;C07K1/00;C12N1/19;C12N15/12;C12N15/63;C12P21/02 |
主分类号 |
C07K14/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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