| 摘要 |
The present disclosure provides polypeptide conjugates comprising a polypeptide moiety and an agent, wherein the polypeptide moiety is linked to the agent through the -amino group of the polypeptide moiety. The present disclosure also provides methods for the manufacture of polypeptide conjugates comprising a polypeptide moiety and an agent, wherein the polypeptide moiety is linked to the agent through the -amino group of the polypeptide moiety. The methods disclosed provide for the selective attachment of the agent to the polypeptide moiety. Furthermore, the method of attachment utilizes mild conditions to link the polypeptide moiety and the agent, thereby maintaining the overall molecular structure of the polypeptide moiety so that is biological activity and/or binding activity is maintained. Such conjugates have many uses, for example in targeting specific cell types, treating disease, preventing disease, and diagnosing disease. |
