| 摘要 |
The invention relates to regulating the level of a membrane-anchored target molecule using PrP or a fragment thereof and a polyanion. Direct or indirect methods for targeting protein downregulation, mediated through PrP or a fragment thereof and a polyanionare are described. This represents a method for treating/preventing a disease, disorder or condition comprising administration to a subject in need of a therapeutically amount of a chimeric protein comprising PrP or a fragment thereof and a protein of interest, the DNA encoding the chimeric protein, the vector encoding the DNA or host cell harboring the DNA encoding the chimeric protein and a subsequent polyanion administration. It provides a pharmaceutical composition comprising a carrier and a chimeric protein comprising PrP or a fragment thereof fused to a protein of interest, the DNA encoding the chimeric protein, the vector encoding the DNA or host cell harboring the DNA encoding the chimeric protein. |
