发明名称 |
Methods of making efavirenz and intermediates thereof |
摘要 |
The present invention provides a process for the preparation of Efavirenz. A compound of Formula 1: may be prepared by a process comprising cyclizing, in the presence of a first base, a compound of Formula 5 with a haloformate of Formula 6. Other processes are also provided as well as novel compounds prepared by and used in such processes. |
申请公布号 |
US8080655(B2) |
申请公布日期 |
2011.12.20 |
申请号 |
US20090505627 |
申请日期 |
2009.07.20 |
申请人 |
CHEN BO;WANG ZHI-XIAN;XUE YUTAO;LIU LIHONG;CHEN HAO;APOTEX PHARMACHEM INC. |
发明人 |
CHEN BO;WANG ZHI-XIAN;XUE YUTAO;LIU LIHONG;CHEN HAO |
分类号 |
C07D265/18 |
主分类号 |
C07D265/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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