| 发明名称 |
METHOD FOR RESERVATROL-BASED OSTEOPOROSIS CORRECTION AND FRAGILITY FRACTURE PREVENTION |
| 摘要 |
FIELD: medicine. ^ SUBSTANCE: reservatrol efficacy is studied in female Wistar rats with simulated osteoporosis by bilateral ovariectomy. For osteoporosis correction, reservatrol is administered in animal intraperitoneally for eight weeks after ovariectomy daily once a day in single dose 2 mg/kg. Osteoprotective action of reservatrol is estimated by a bone tissue microcirculation level and width of trabeculas of bone. ^ EFFECT: improved blood circulation and microarchitectonics of bone tissue in hypoestrogenic condition. ^ 1 tbl, 1 ex |
| 申请公布号 |
RU2437161(C1) |
申请公布日期 |
2011.12.20 |
| 申请号 |
RU20100114473 |
申请日期 |
2010.04.12 |
| 申请人 |
GOSUDARSTVENNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "KURSKIJ GOSUDARSTVENNYJ MEDITSINSKIJ UNIVERSITET FEDERAL'NOGO AGENTSTVA PO ZDRAVOOKHRANENIJU I SOTSIAL'NOMU RAZVITIJU" |
发明人 |
POKROVSKIJ MIKHAIL VLADIMIROVICH;GUDYREV OLEG SERGEEVICH;FAJTEL'SON ALEKSANDR VLADIMIROVICH;KOKLINA NATAL'JA JUR'EVNA;ARTJUSHKOVA ELENA BORISOVNA;POKROVSKAJA TAT'JANA GRIGOR'EVNA;KOROKIN MIKHAIL VIKTOROVICH;KOROKINA LILIJA VIKTOROVNA;BELOUS ALEKSANDR SERGEEVICH;KOCHKAROV VLADIMIR ISKHAKOVICH;DANILENKO LJUDMILA MIKHAJLOVNA;GLADCHENKO MIKHAIL PETROVICH;GUREEV VLADIMIR VLADIMIROVICH;KOLESNIK INGA MIKHAJLOVNA;STABROVSKAJA NADEZHDA VLADIMIROVNA;RAGULINA VERA ALEKSEEVNA;IVANOV ALEKSANDR VIKTOROVICH;JAKUSHEV VLADIMIR IVANOVICH |
| 分类号 |
A61K31/045;A61P19/10;G09B23/28 |
主分类号 |
A61K31/045 |
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