发明名称 |
METHOD FOR SELECTIVE OLIGONUCLEOTIDE MODIFICATION |
摘要 |
Method for producing a modified oligonucleotide, wherein at least one polymer, preferably polyalkylene oxide, and/or a compound is covalently bound to the 5´-end or the 3´-end of the oligonucleotide via native ligation forming a native ligation site, with the proviso that the polymer and/or the compound is not a protein or peptide, if only the 5´-end of the oligonucleotide is modified by binding of the polymer or compound via native ligation. The invention is further directed to a modified oligonucleotide obtainable by the inventive method as well as the use of such modified oligonucleotide for the preparation of a medicament for preventing and/or treating a tumor, formation of metastasis, an immune disease or disorder, a cardiovascular disease or disorder, and/or a viral disease or disorder. |
申请公布号 |
WO2011154542(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
WO2011EP59744 |
申请日期 |
2011.06.10 |
申请人 |
ARTISENSE PHARMA GMBH;MITSCH, ANDREAS;SCHLINGENSIEPEN, KARL-HERMANN;BETZIER, BERND;JASCHINSKI, FRANK;SCHNEIDER, ANNELIESE |
发明人 |
MITSCH, ANDREAS;SCHLINGENSIEPEN, KARL-HERMANN;BETZIER, BERND;JASCHINSKI, FRANK;SCHNEIDER, ANNELIESE |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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地址 |
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