发明名称 |
MULTIVALENT AND/OR MULTISPECIFIC RANKL-BINDING CONSTRUCTS |
摘要 |
The invention relates to a combination of RANKL antagonists with OSM antagonists, and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof |
申请公布号 |
US2011305694(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
US201013203003 |
申请日期 |
2010.02.23 |
申请人 |
HAMBLIN PAUL ANDREW;PARMAR RADHA SHAH;WHITE JOHN |
发明人 |
HAMBLIN PAUL ANDREW;PARMAR RADHA SHAH;WHITE JOHN |
分类号 |
A61K39/395;A61P19/02;A61P19/08;A61P35/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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