| 发明名称 |
MOUSE HAVING HUMAN LEUKEMIC STEM CELL AND LEUKEMIC NON-STEM CELL AMPLIFIED THEREIN, AND METHOD FOR PRODUCTION THEREOF |
| 摘要 |
The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgnull mouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addition, the invention relates to screening for a medicament capable of eradicating leukemic stem cell (LSC), consideration of treatment methods suitable for individual patients, identification of a differentially expressed gene and the like, using a mouse with expanded human leukemic cells.
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| 申请公布号 |
US2011307964(A1) |
申请公布日期 |
2011.12.15 |
| 申请号 |
US20080738559 |
申请日期 |
2008.10.17 |
| 申请人 |
ISHIKAWA FUMIHIKO;SAITO YORIKO;OHARA OSAMU;SHULTZ LEONARD D.;THE JACKSON LABORATORY;RIKEN |
发明人 |
ISHIKAWA FUMIHIKO;SAITO YORIKO;OHARA OSAMU;SHULTZ LEONARD D. |
| 分类号 |
A61K39/395;A01K67/027;A61K49/00;A61P35/02;C07K16/30;C12Q1/18;C40B30/04;G01N33/53 |
主分类号 |
A61K39/395 |
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