KINASE INHIBITORS

摘要

The present invention relates to inhibitors of kinases. In particular, the invention relates to methods of screening for inhibitors of the JAK family of kinases which bind JAK but which are non-competitive for ATP and/or JAK substrate. A JAK inhibitor that is non-competitive toward substrate is unaffected by the high local substrate concentration and therefore is more effective in vivo. Non-competitive inhibitors of the invention, and/or identified by using methods of the invention, can be used in the treatment or prevention of diseases resulting from dysregulated JAK activity, for example cancer and/or a myeloproliferative disorder.