发明名称 |
PROCESSES FOR THE MANUFACTURE OF 3--PYRIDINE, 4-METHYL-3-METHYLTHIO-5-(3-PYRIDYL)-L,2,4-TRIAZOLE, AND (1R)-1-[2-(3-METHYLPHENYL)-2H-TETRAZOL-5-YL]ETHANOL |
摘要 |
The present invention provides a process for the manufacture of the compound 3-{4-methyl-5-[(1R)-1-(2-(3-methylphenyl-2H-tetrazol-5-yl)-ethoxy]-4H-[1,2,4]triazol-3-yl}-pyridine of formula 14 wherein a) the compound 3-(5-methane-sulfonyl-4-methyl-4H-1,2,4-triazol-3-yl)-pyridine of formula 6 and the compound (1R)-[2-(3-methylphenyl)-2H-tetrazol-5-yl]ethanol of formula 13 are dissolved in an aprotic solvent, whereafter an alkoxide base is added, providing the compound of formula 14. The invention also provides methods for manufacturing 3-(5-methanesulfonyl-4-methyl-4H-1,2,4-triazol-3-yl)-pyridine and (1R)-1-[2-(3-methylphenyl)-2H-tetrazol-5-yl]ethanol. |
申请公布号 |
US2011306768(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
US200913140454 |
申请日期 |
2009.12.11 |
申请人 |
ELFYN JONES;LARSSON ULF G.;ASTRAZENECA AB |
发明人 |
ELFYN JONES;LARSSON ULF G. |
分类号 |
C07D401/14;C07D257/04;C07D401/04 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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地址 |
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