发明名称 |
LABELED INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA), BIOLOGICAL EVALUATION, AND USE AS IMAGING AGENTS |
摘要 |
<p>The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or without a variable length linker moiety. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+PC3 PIP tumors.</p> |
申请公布号 |
EP2170075(A4) |
申请公布日期 |
2011.12.14 |
申请号 |
EP20080779786 |
申请日期 |
2008.06.26 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
POMPER, MARTIN, GILBERT;RAY, SANGEETA;MEASE, RONNIE, C.;FOSS, CATHERINE |
分类号 |
C07D213/38;A01N47/28;A61K31/145;A61K31/17;A61K31/195;A61K31/395;A61K31/4402;A61K38/06;A61K51/04;C07D215/12;C07D257/00;C07F13/00;G01N33/574 |
主分类号 |
C07D213/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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