发明名称 |
A MEK 1 MUTATION CONFERRING RESISTANCE TO RAF AND MEK INHIBITORS |
摘要 |
Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEKl sequence are also provided. |
申请公布号 |
CA2799790(A1) |
申请公布日期 |
2011.12.15 |
申请号 |
CA20112799790 |
申请日期 |
2011.06.09 |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
GARRAWAY, LEVI A.;EMERY, CAROLINE;WAGLE, NIKHIL |
分类号 |
C12N9/12 |
主分类号 |
C12N9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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