NATIVE NAD-DEPENDENT GAPDH REPLACED WITH NADP-DEPENDENT GAPDH PLUS NADK

摘要

This invention is metabolically engineered bacterial strains that provides increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NAPP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided.